A Comparative Study Between Efficacy Of Povidone Iodine Versus Isopropyl Alcohol In Pre-Operative Skin Preparation In Preventing Ssi In Elective Open Procedures

Abstract

Surgical site infections (SSIs) are a significant concern in elective surgical procedures, contributing to increased morbidity and healthcare costs. Preoperative skin antisepsis plays a crucial role in reducing the risk of SSIs. This prospective, comparative study investigates the efficacy of two commonly used antiseptics, Povidone-Iodine and Isopropyl Alcohol, in preventing SSIs in patients undergoing elective open procedures. A total of 230 patients were randomly assigned into two groups: Group A (115 patients) underwent skin preparation with Povidone-Iodine, while Group B (115 patients) received Isopropyl Alcohol. The primary outcome was the incidence of SSIs, with secondary outcomes including postoperative wound healing, hospital stay duration, and patient satisfaction. Results showed no statistically significant difference in the incidence of SSIs between the two groups (p=0.95). However, Isopropyl Alcohol demonstrated a slightly quicker wound healing time, while Povidone-Iodine showed better sustained microbial reduction. Both agents were well tolerated, with no severe adverse reactions reported. This study concludes that both Povidone-Iodine and Isopropyl Alcohol are effective in preventing SSIs, with each agent having distinct advantages. Clinicians may choose between these agents based on patient-specific factors and procedural requirements. Further studies with larger sample sizes and different surgical settings are recommended to establish definitive guidelines for antiseptic selection.