A Review of the Synthesis and Biological Activities of a Multitarget Core of Unicyclic β-Lactam

Abstract

The most significant and fascinating publications on the synthesis of novel β-lactam compounds with various biological activities that have been released since 1977 are comprehensively covered in the current section. The various synthetic tactics that are accessible are discussed, including both new and well-established but effective and adaptable approaches. Simple changes to one or more substituents connected to the β-lactam nucleus's nitrogen and carbon atoms were taken into consideration as a different synthetic procedure for more intricate and multifunctional compounds. In this article, other marketed β-lactam derivatives are also expressed.  The biological activity of this strained four-membered heterocycle is, in fact, well known and widely reviewed to be solely dependent on the type of substituent groups that alter the reactivity towards the molecular active sites, thereby increasing or decreasing the likelihood of interaction with the substrates. An overview of the most important pharmacological and biological uses of 2-azetidinones is finally presented.