Crude Plant Extracts with Anti-Diabetic Potential: Revisiting Traditional Herbal Remedies for Diabetes Care

Abstract

Background: The objective of this investigation was to assess the anti-diabetic properties of the aqueous and alcoholic extracts in diabetic rodents that had been induced with alloxan.

Approaches: Following an acute toxicity test, alloxan was implemented to induce diabetes in Swiss albino rodents for scientific purposes. The two-week fasting mean blood glucose level in normal, diabetic mice that were not treated, and diabetic mice that were treated with alcoholic and aqueous extracts was the subject of the investigation. The Statistical Package for the Social Sciences, Version 20, was employed to conduct a statistical analysis of the data. Statistically significant was defined as a P-value that was less than 0.05.

Results: The extracts were found to contain steroids, phenolic compounds, flavonoids, and terpenes following phytochemical screening. These substances may have an effect on the extracts' anti-diabetic properties. Nevertheless, the preparations were devoid of anthraquinones and alkaloids.

Conclusion: The Alcohalic extract (200 mg/kg) exhibited the highest percentage reduction in blood glucose levels, and the ability of Hibiscus syriacus extracts to reduce blood glucose levels is likely due to the presence of antioxidant constituents, such as flavonoids.