Comparative Efficacy Of 308 Nm Excimer Laser Monotherapy Versus Combination Therapy With Topical Agents In Treating Localized Plaque Psoriasis

Abstract

This study evaluates the comparative efficacy of 308 nm excimer laser monotherapy versus combination therapy with topical agents (corticosteroids and vitamin D analogs) in the treatment of localized plaque psoriasis. While excimer laser monotherapy has demonstrated effectiveness in reducing plaque size, thickness, and scaling, a significant portion of patients (24%) did not achieve satisfactory results. In contrast, the combination therapy showed faster lesion clearance, extended remission periods, and a more comprehensive therapeutic response. The synergistic effects of excimer laser and topical therapies contribute to improved patient outcomes, particularly for resistant psoriasis cases. However, challenges such as patient adherence to follow-up visits and potential adverse effects of prolonged corticosteroid use were noted. The study suggests that combination therapy offers superior results but must be tailored to individual patient needs, considering both the benefits and risks. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings and explore alternative treatments.