To Study The Correlation Of Leptin And Adiponectin As A Promising Biomarker In Obese And Non Obese Women With Polycystic Ovary Syndrome Patients.

Abstract

Background: Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many women of childbearing age. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology and pathophysiology are not comprehensively understood yet. Circulating leptin has a high correlation with obesity, which is usually linked to polycystic ovarian syndrome (PCOS). Adiponectin is a circulating protein produced by adipocytes. Circulating adiponectin levels are inversely proportional to adipocyte mass. Aim and Objective: Assessing the correlation of Leptin and Adiponectin as a predictive marker in Obese And non Obese Women with Polycystic Ovary Syndrome Patients. Material and Methods: This was a Case control study carried out in the Department of Biochemistry with collaboration with the Obstetrics and Gynaecology Department.

The study

comprised of 200 patients with PCOS and 200 controls without PCOS. Each group was analyzed for the following parameters as TSH, Prolactin, FSH, LH, AMH, Total cholesterol, Systolic/diastolic (BP), BMI, Leptin, Adiponectin, MDA(Malondialdehyde) and SOD (Superoxide dismutase). Results: In the present study it was observed that the maximum number of cases was recorded in the age group of 20-30 years of age for the PCOS as well as for the controls with 124 (62%) and 120 (60%) respectively. Oligomenorrhea in case of PCOS was 65% and in controls was 38.5% as there was increased cases of Oligomenorrhea in PCOS cases compared to the (control group). The increased level of leptin among women with PCOS was positively associated with FSH, LH, TSH, Total cholesterol, MDA in PCOS whereas Adiponectin was negatively correlated. Conclusion: The relationships between leptin and adiponectin and insulin resistance and sensitivity, metabolic syndrome, and BMI in women with PCOS suggest that Leptin and Adiponectin potentially could serve as a marker for disease risk and provide opportunity for earlier intervention if knowledge is successfully translated from laboratory to clinical practice.