Synthesis and Characterization of Silver Nano Particles of Kaempferol and Their Application as Antibacterial and Against Prostate Cells (Pc-3)

Abstract

 Background: Silver nanoparticles (AgNPs) have demonstrated a broad range of antibacterial & anti-cancer activities during the last 20 years.

Aim: The current endeavor seeks to produce kaempferol silver nanoparticles that are favourable to the environment.

Materials and Methods: Green synthesis of silver nanoparticles was prepared. Nano particles was subjected to different analysis such as FTIR, SEM, XRD and antimicrobial assay with pseudomonas and PC3 cell lines were used for the determination of anticancer potential of kaempferol silver nanoparticle.

Results: The n-H stretch of the amine was identified in the FTIR analysis of the nanoparticles as a peak at 3335 cm-1, whereas a tiny O-H stretch was seen at 3442 cm-1. At 2538 cm-1, the absorption peak of the C-H stretch alkyne was found. With its assistance, the C-O asymmetric stretch carbon compounds were synthesized. A band at 1598.00 cm-1 was used to express the C-O asymmetric stretch carbon compounds. Additionally expressed were the C-X alkyl halides and the C-O-C asymmetric stretch carbon compounds at bands of 551, 526, and 512 cm-1. According to our research, the several functional groups that kaempferol-coated AgNPs contain help to stabilize them. The sample exhibited inhibiting effects on Pseudomonas, and antimicrobial assays were conducted using test compounds against test organisms, the zone of inhibition seen against test chemicals and standard. The findings demonstrated that nanoparticles decreased cellular motility and PC 3 (prostate cancer cell) cell proliferation. AgNO3 was used in cell-based cytotoxic tests at different concentrations.

 Conclusion: The results of the study show that kaempferol has more potent antibacterial and anticancer effects when it is present in the form of silver nanoparticles.