Quercetin-loaded Solid Lipid Nanoparticles: Preparation and Characterization for Biomedical Application

Abstract

In the proposed work, quercetin (QuR) loaded solid lipid nanoparticles (Q-SLNs) were prepared for biomedical applications using the nano-biomaterials of solid lipid, such as stearic acid (SA), and the surfactants tween 80 and span 80. The % drug loading and entrapment efficiency (EE (%)) for the optimized Q-SLN were 94.21 ± 6.44 % and 76.87 ± 8.2 %, respectively. There were strong relationships between the QuR incorporation and release patterns. Effective QuR delayed release was demonstrated by the results, which showed that over 63.45 ± 2.14 % of the bio-nano Q-SLNs was released gradually over the period of 60 h. Overall, the drug had been successfully loaded into the SLN, exhibiting a physicochemical compatibility without any chemical interaction with the used additives. According to the results, Q-SLN is the best vehicle for delivering QuR, and this preparation is utilized in a variety of treatments.