Formulation and In vitro Characterization of Syzygium Cumini Chitosan (Poly-[D-glucosamine]) Nanoparticles for Diabetes.

Abstract

                  The study aims to develop chitosan encapsulated nanoparticles for the leaf extract of Syzygium cumini targeting effective management of diabetes. Traditionally, Syzygium cumini (commonly known as jamun) is well known for its ability to control diabetes. To increase its effectiveness as a remedy, special nanoparticles were created from Syzygium cumini extract with the goal of enhancing its absorption and overall therapeutic benefits. The particle size of these nanoparticles were analyzed using methods such, as Dynamic light scattering (DLS) and their morphology was scanned through electron microscopy (SEM). The particle size of  nanoparticles were found to be 355 nanometers and their stability was measured through zeta potential (+24.65 millivolts). Anti diabetic activity were evaluated using enzyme inhibition tests that focused on alpha amylase, alpha glucosidase and beta glucosidase. Which, enzymes critical, in metabolism. The nanoparticles displayed inhibition levels; 75 % for alpha amylase 74 % for alpha glucosidase and 78 %, for beta glucosidase enzymes. The results indicate that nanoparticles derived from Syzygium cumini show improved effectiveness, in managing diabetes. Could be an approach for diabetes treatment going forward suggesting the need for additional research to ensure their safety and effectiveness over time, in practical experiments.