Evaluation Of Formulation Development And Stability Studies Of Liquisolid Drug Metoprolol Succinate

Abstract

One possible approach to developing prolonged release devices is to optimize liquisolid technology in such a way that the drug dissolves at a slower rate. In this experiment, metoprolol succinate was dispersed in polyethylene glycol 400, a liquid medium. Subsequently, the medication was continuously combined in a mortar with a binary mixture of carrier-coating materials (Avicel PH-102). Using the tablet compression machine to compress the mixture was the last stage. Metoprolol succinate's release profile from liquisolid compacts was to be investigated in relation to drug contents, loading factors, and heat treatments. Metoprolol succinate release rates from matrix tablets and liquisolid compacts were examined. In terms of retardation, matrix tablets were surpassed by metoprolol succinate tablets made using the liquisolid process. The results of this study show that hydroxypropyl methylcellulose (HPMC) is crucial for the maintenance of drug release in liquisolid tablets. I also found out that wet granulation significantly slowed the rate of medication release of metoprolol succinate from liquisolid compacts. Storage of the liquid-solid tablets at 400C and 75% relative humidity for three months demonstrated that the drug's dissolving profile and hardness stayed consistent with age. The majority of the liquisolid formulations exhibited a zero-order release pattern, as demonstrated by the kinetics measurements. Liquisolid formulations did not undergo any changes in crystallinity or complex formation, according to infrared spectroscopy and differential scanning calorimetry (DSC).