Score to Save: Revolutionizing Esophageal Cancer Screening with Multifaceted Indicators

Abstract

Introduction

Esophageal cancer remains a signi cant global health concern, with challenges in early detection and screening. This study addresses the existing gaps in esophageal cancer screening by developing a scoring system utilizing eight key indicators: acid reux, gender, age, smoking (in pack years), alcohol consumption (beverages per week), location of residence, genetic predisposition, pre-existing gastroenterological conditions and obesity measured by BMI. The aim is to enhance the accuracy and e ciency of early detection through a multifaceted approach.

Material & Methods

Our methodology involved a rigorous meta-analysis of numerous studies published from 2013 to 2023 to identify the most reliable indicators for esophageal cancer risk. Data from diverse populations were synthesized, ensuring a comprehensive and representative analysis. The scoring system was developed through statistical modeling, assigning weights to each indicator based on their significance. The model's validity and reliability were assessed through

cross-validation and comparison with existing screening methods.

Results The key findings reveal a robust scoring system that effectively integrates the selected indicators, providing a nuanced and accurate assessment of esophageal cancer risk. Notably, indicators such as acid reflux, smoking history, and genetic predisposition emerged as strong predictors. The model demonstrated superior sensitivity and specificity compared to current screening methods. Subgroup analyses highlighted variations in risk patterns across different demographics and geographic locations.

Conclusion

In conclusion, our research establishes a novel scoring system for esophageal cancer screening, utilizing a combination of eight indicators. This approach o ers a more nuanced and personalized risk assessment, potentially leading to earlier detection and improved outcomes. As we move forward, the integration of this scoring system into routine screening protocols holds promise for enhancing preventive strategies and reducing the burden of esophageal

cancer. Future perspectives include prospective validation studies and continuous renement of the scoring system based on emerging research and technological advancements.