Kudzu root and maqui berry extract preclinical assessment in streptozotocin-induced nephropathy

Abstract

Background and Objectives: A metabolic problem related to diabetes mellitus is hyperglycemia, which happens when the body doesn't make enough insulin. Nephropathy is a major capillary problem that can happen with diabetes. The purpose of this study is to find out how well Maqui berry and Kudzu root products can stop experimental mice from getting nephropathy caused by diabetes.

Methods: Streptozotocin (55 mg/kg) was given intraperitoneally to male Wistar rats that weighed 200–250 g to make them develop diabetic nephropathy. To check for nephritis biochemically, blood glucose, total protein, albumin, urea, uric acid, creatinine, and total bilirubin were measured in serum and urine. Along with membrane-bound ATPases, lipid peroxidation, reduced glutathione, and superoxide dismutase were used to measure signs of oxidative stress.

Results: Nephropathy rats were given extracts from kudzu roots and maqui berries by mouth for two weeks. The doses were 50 mg/kg orally for kudzu and 100 mg/kg orally for maqui. Rats with diabetic nephropathy had much higher levels of creatinine, albumin, total protein, total bile, uric acid, urea, and signs of oxidative stress like lipid peroxidation. On the other hand, their levels of superoxide dismutase and glutathione were much lower. Over the course of two weeks, treatment with 50 mg/kg and 100 mg/kg of Kudzu root extract and 50 mg/kg and 100 mg/kg of Maqui berry extract, either alone or together, changed the levels of oxidative stress markers, ATPases, and biomarkers of renal function, getting closer to normal levels.

Conclusion: Synergistic benefits in decreasing oxidative stress indicators and hyperglycemia, thereby alleviating renal injury, were shown when Kudzu root extract and Maqui berry extract were used together, according to current research.