Investigation Of The Analgesic And Anti-Inflammatory Activity Of A Newly Synthesized 1,2,3-Triazole Derivative

Abstract

In our research, we investigated the analgesic and anti-inflammatory activity of 4-(4-((4-formylphenoxy)methyl)-1H-1,2,3-trizol-1-yl)benzoic acid, a newly synthesized derivative of 1,4-substituted 1H-1,2,3-triazole. The studied substance demonstrated analgesic activity of 70.7% in the “Hot plate” test at a dose of 100 mg/kg, 81% in the “Acetic acid writhing” test at a dose of 50 mg/kg, and 79% in the “Acetylcholine writhing” test at a dose of  50 mg/kg. The anti-inflammatory activity of the substance under study - 4-(4-((4-formylphenoxy)methyl)-1H-1,2,3-trizol-1-yl) benzoic acid - was studied in the "formalin paw edema" model, showed 49.1% activity at a dose of 100 mg/kg. When we studied the profile of inflammatory and anti-inflammatory cytokines in serum, it was found that 4-(4-((4-formylphenoxy)methyl)-1H-1,2,3-trizol-1-yl) benzoic acid at a dose of 100.0 mg/kg increased the level of the anti-inflammatory cytokine IL-4 by 1.5 times compared to the control group, and decreased the levels of the inflammatory cytokines IL-6 and α-FNO by 1.5 and 2.4 times, respectively.