Formulation and Assessment of Topical Gel Containing Ocimum gratissimum Derived Silver Nanoparticles for the Treatment of Acne

Abstract

Background: Nearly eighty percent of all teenagers will deal with acne vulgaris, a common skin condition. Resistance develops when a certain drug-bacteria interaction occurs over an extended period of time. Discovering the phytochemical content of Ocimum gratissimum, developing an environmentally friendly method of producing silver nanoparticles, and creating a plant gel to treat acne were the objectives of this study.

Methods: Ocimum gratissimum is an excellent option due to its antibacterial properties. Alkaloids, flavonoids, tannins, and saponins are some of the phytoconstituents identified in the phytochemical analysis of the extract. One millimoles of silver nitrate in one milliliter of water was prepared using Ocimum gratissimum extracts. The next step was to confirm the synthesis of silver nanoparticles using ultraviolet spectroscopy.

Results: After adding the produced silver nanoparticles to the gel basis, scientists examined its viscosity, pH, and ability to disseminate and kill the microorganisms Propionibacterium acnes, Staphylococcus aureus, and Escherichia coli. There were no lumps, fibers, or fragments in the final product; the colors were distributed uniformly. It was also seen to be easily removed and to have a strong spreading potential.

Conclusion: Because of this, Ocimum gratissimum silver nanoparticles mixed with a watery gel may work well to treat acne vulgaris.