High Salt-Induced Hypertensive activity and Evaluation of antihypertensive activity of Sateria glauca in ethanolic extract

Abstract

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This study sought to assess, using a rat model, the antihypertensive effects of Setaria glauca (SG) ethanolic extract. Hypertension was caused over the course of six weeks by adding 6% NaCl to the diet. Here we divide rats into four groups Group1, Group2, Group3 and Group4, each group having four rats. Group1 was treated with high salt intake in wate and food. Group 2 was exposed with to 6% NaCl and treated with drug telmisartan (Which is an antihypertensive drug 10 mg/kg). Groups 3 and 4 were experimental groups, where hypertension was induced using 6% NaCl, followed by daily oral administration of segregated dose of SG 100 mg per kg and 200 mg/kg body weight respectively for five weeks. The treatment shows significant downfall in blood pressure (pressure <0.05mmHg), heart rate and have diuretic response in hypertensive rats. It shows that the SG effect is dose dependent. These results highlight the potential of SG as an effective antihypertensive agent in managing salt-induced hypertension.