Determination Of Anti-Inflammatory Potential Of Endangered Plant Species Of Western Ghats

Abstract

NSAIDs used to treat inflammatory conditions only alter the inflammatory response to the diseases, not the underlying cause of the disease. Therefore, there is resurgence to search for orally active molecules that are more effective than currently available medications at treating the underlying causes of inflammatory disease as opposed to just the symptoms. Hence, current study aimed to assess the anti-inflammatory activities of endangered plant species of western ghats against murine monocytic macrophage RAW 264.7 cell line. Results depicted that all the three endangered plant species of Western ghats viz. C. zedoaria, S. travancorium, and P. vettiveroides, exhibited anti-inflammatory properties. However, stem extract of endangered plant species of western ghat viz. S. travancorium has shown highest anti-inflammatory activity with mean inhibition of 39.75 compared with other two plant species viz. C. zedoaria and P. vettiveroides. In conclusion, stem extract of endangered plant species of western ghat S. travancorium possesses potent anti-inflammatory properties, and hence it could be considered for the development of natural anti-inflammatory drug agents.