Recent Trends in Floating Drug Delivery Systems (FDDS) or Hydro dynamically Controlled Systems: A Novel Approach for Solubility

Abstract

Floating drug delivery systems (FDDS) or hydro dynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. These buoyant delivery systems utilize effervescent reactions between carbonate/bicarbonate salts and citric/tartaric acid to liberate CO2, which gets entrapped in the gellified hydrocolloid layer of the systems thus decreasing its specific gravity and making it to float over chyme. Over past 30 year as the expanse and complication involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. There are several reasons for the attractiveness of these dosage forms. It is generally recognized that for many disease states, a substantial number of therapeutically effective compounds already exist. The concept of targeting i.e. site specific drug delivery is a well established dogma, which is gaining full attention. Placement of the particles indiscrete anatomical compartment leads their retention either because of the physical properties of the environment of biophysical interaction of the particles with the cellular content of the target tissue.