Evaluation of Phytochemical Screening Anti-Convulsant Activity of Ethanolic Extract of Plumbago Zeylanica

Abstract

The purpose of this study is to explore the anticonvulsant effect of the leaf gall extract of Plumbago zeylanica using pentylene tetrazole-induced convulsion (PTZ) in rats Plumbago zeylanica is an indigenous plant belonging to the family Fabaceae (Papilionaceae) commonly known as Karanj. Freshly powdered flowers were extracted with 70% ethanol. The convulsion is induced by the administration of pentylene tetrazole (80 mg/kg, i.p.) to wistar albino rats, and those showing response was divided into three groups of six animals each. The group I treated with 1% normal saline (1ml/100gm, orally), Groups II treated with phenytoin sodium (25\mg/kg, i.p.) and Groups III treated with ethanolic extract at a dose of (250 mg/kg, i.p.). The ethanolic extract showed significant anticonvulsant activity by lowering the duration of the extension phase (3.72 ± 0.65) when compared to the control group (8.94 ± 0.42). From the experiment, we can say Plumbago zeylanica had significant anticonvulsant activity.