A Study On Prevalence &Determinants Of HPV In High-Risk Women In The Age Group (30-59yrs) Attending Gynecology OPD Of A Tertiary Care Hospital Of Jharkhand.

Abstract

Background: Human papillomavirus is an STD that generates malignancies of the genital tract, including cervical cancer. Persistent HPV infection is linked to the development of cervical carcinoma. In order to lessen the impact of cervical cancer and encourage cancer registration, epidemiological data on the prevalence, distribution, and conditions of HPV are essential. The study aimed to estimate the prevalence and determinants of HPV infection in women aged 30-59 in the Kolhan region of Jharkhand.

Material & Methods: A cross-sectional study was conducted over a period of two years from January 2022 to December 2023 at a tertiary care teaching hospital in Jharkhand. We enrolled a total of 321 women (30-59 years) for the study. We screened all participants for HPV molecular testing and collected demographic data through a standard questionnaire. The study used a chi-square test to correlate qualitative variables, and a P-value <0.05 was considered statistically significant.

Results: The study found that the overall prevalence of HPV infections was 23/321 (7.2%). There is a high prevalence of HPV in (32-34 years) at 34.8% and in (45-49 years) at 26.1%. The prevalence of HPV was 13% in tribal women. The results showed no statistical significance. In this study, the most prevalent genotypes were multiple groups of HR HPV genotypes (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68), followed by HPV 16 and HPV 18.

Conclusion: The Kolhan division of Jharkhand has a high prevalence of high-risk HPV, particularly among women aged 30-34 and 45-49, recommending rural-based cervical screening and vaccination programs.