High-performance RGO-Pt-PEDOT Nanosensor for Phenobarbital and Primidone Electrochemical Analysis
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Abstract
Abstract: With the use of a modified glassy carbon nanosensor that had been modified by reduced graphene oxide-platinum NPs-poly(3,4-ethylenedioxythiophene) (RGO-Pt-PEDOT). This work presents the validation and development of a new electro-chemical technique for the simultaneous determination regarding phenobarbital as well as primidone. The approach uses differential pulse voltammetry in Britton-Robinson buffer (pH 7). The approach demonstrated high accuracy, precision, and selectivity. Under optimum conditions, the nanosensor exhibited linear responses for both phenobarbital and primidone in 1.0-100μg/mL and 1.50-120μg/mL ranges, respectively, with detection limits of 0.3μg/mL and 0.50 μg/mL. This sensitive, rapid, and economical method offers a viable substitute for conventional chromatographic approaches for quality control regarding such anticonvulsant drugs. It has been efficiently applied to commercial pharmaceutical formulation analyses, demonstrating good agreement with a reference HPLC method.
Phenobarbital; Primidone; Nanosensor; Voltammetry; RGO-Pt-PEDOT; Pharmaceutical analysis; Electrochemical detection.