Reviewing Bioenhancers in Traditional Indian Medicine: Exploring their Potential Mechanisms and Applications

Abstract

Background: Natural bioenhancer is a natural substance that can improve the effectiveness and absorption of a drug or nutrient when combined with it, without displaying any typical pharmacological activity at the dosage used. By using natural bioenhancers, the required dose can be reduced, the treatment duration shortened, and the recovery rate increased. The main mechanisms underlying phyto-bioenhancers involve influencing drug absorption, such as affecting solubility, drug efflux, and transport proteins, increasing permeability in the gastrointestinal system, and affecting drug metabolism by inhibiting or inducing drug metabolizing enzymes and producing a thermogenic effect. This study explores the concept ,potential mechanisms and applications of bioenhancers  in traditional Indian medicine, particularly Ayurveda.

Methods: The review will likely discuss relevant scientific literature on bioenhancers in traditional Indian medicine, focusing on their mechanisms of action and documented applications. It might also explore historical references to bioenhancers in Ayurvedic texts like Charaka Samhita and SushrutaSamhitafor references to "Anupana" and "Yogavahi," terms associated with bioenhancement. It further investigates the categorization of bioenhancers and the use of examples like piperine (black pepper) and "Trikatu" (ginger, black pepper, long pepper) in Ayurvedic practice.

Results: The research demonstrates a long-standing tradition of using bioenhancers in Ayurveda. Historical understanding was based on empirical evidence, while contemporary research is unveiling the scientific mechanisms behind their efficacy.

Conclusion: The study highlights the significance of bioenhancers in traditional Indian medicine and emphasizes the importance of scientific inquiry for validating and integrating these practices into modern healthcare. The potential of bioenhancers in traditional Indian medicine and pave the way for further research on their mechanisms and applications in modern healthcare.