Lane Tumor with lame prognosis: An unusual case report.

Abstract

According to WHO 2020, Lane tumor commonly called as Spindle cell squamous carcinoma (SCSC) is classified under malignant epithelial tumors, a monoclonal dedifferentiated form of conventional squamous cell carcinoma accounting only 1%. Though a rare variant, it represents an aggressive bimorphic/biphasic neoplasm exhibiting poor survival outcome, increased metastasis and recurrence. A 67-year-old male reported with an ulcerated nodular growth in the oral cavity, diagnosed as SCSC on incisional biopsy. It was T4N1M0. The management call was neo-adjuvant chemotherapy instead of surgical resection with radical neck dissection as it was too morbid. Unfortunately, the patient expired within 2 months of diagnosis before completing the planned chemotherapy cycles. This unusual case is documented because of sarcomatoid component which can mislead histopathological diagnosis with various other similar looking reactive, benign and malignant lesions and its worst prognosis, making SCSC one of the most challenging and interesting of all the head and neck tumors.