Design, Synthesis And In Silico Studies Of Chalcone-Based Tetralone Derivatives For Biological Activity

Abstract

The goal of this research is to create hybrid compounds "by" combining chalcone and tetralone into a single structure that might have better antibacterial properties. Five distinct compounds were synthesised in all. Infrared spectroscopy, elemental analysis, and melting point were used to characterise the synthesised substances. The compounds that were synthesised demonstrated anti-bacterial and antifungal characteristics, according to anti-bacterial and antifungal screening. All three compounds fit the target protein's active site with PDB ID: 1M17, according to molecular docking studies. The substances satisfied Lipinski's rule of five, according to in silico pharmacokinetic study, and can be suggested as potential drugs.