Comparative Pharmaceutico-Analytical Study of Classical, Yashada Bhasma and Potentiated Yashada Bhasma

Abstract

Bhasma in Ayurveda are nano-sized particles prepared using unique methods of incineration that are reported for increased bio-availability and therapeutic outcome, when such methods are aided with techniques to further initiate size-reduction it may give rise to therapeutically modified and potent bhasma than the ones prepared as per classical lines. Hence the present study attempts to curate Potentiated Yashada Bhasma (PYB) by altering few processing methods to the existing incineration methods of Yashada Bhasma (CYB) mentioned in classics. Following general and specific purification techniques, PYB was prepared by subjection of ball milling and wet grinding for specified duration as additional steps to the existing method of preparation of CYB. Both the samples prepared passed all classical tests of bhasma. The physico-chemical changes revealed changes in total ash, acid insoluble ash and loss on drying. Instrumental techniques using DLS detected particle size of PYB (261.1nm) much lower than CYB (696.3nm). The stability of PYB in Zeta Potential (-28mV) was found satisfactory, thus indicating proper preparation of PYB. The study suggests the effectiveness of potentiation techniques that could be adopted logically to the existing classical methods to considerably reduce operational costs and achieve better therapeutic outcomes in lower doses than required.