Development And Characterization Of Sustained Release Tablets Using Tamarind Seed Gum

Abstract

sustained-release tablet of Aprepitant was made using TG which was utilized as a binder. Box Behkhen design (BBD) was used for optimization. Three independent variables as Microcrystalline cellulose (X1), Tamarind gum extract (X2), and Dicalcium phosphate (X3), and dependent variables as Percentage Drug release at 1 hour (Q1), Percentage Drug release at 12 hr (Q12) and Time required for 50% drug release (t50%). Granules made using the wet granulation process were found to be free-flowing since pre-compression characteristics such as bulk density, tapped density, angle of repose, and Hauser's ratio were within the range specified in the official standard. The produced tablets were tested for hardness, friability, weight fluctuation, disintegration time, and drug content after compression. The results were found to be within the permitted official limits. The FT-IR spectrum did not show the presence of any additional peaks for new functional groups indicating no chemical interaction between the drug and TG.  The cumulative proportion of drug release was shown to be much lower as the concentration of natural TG increased. Formulation AF4 was chosen as the best formulation after an in-vitro release research, and it was tested for stability for 90 days.  The stability investigations confirmed that the created tablet formulation remained unchanged in terms of its physical appearance, drug content, and in-vitro drug release properties, thereby confirming that the tablet was stable.