Serum Nse Level And Incidence Of Pod In Post-Traumatic Spinal Surgery With General Anesthesia

Abstract

Introduction: Due to its high incidence and mortality, post-traumatic spinal trauma affects society. Post-traumatic spinal trauma occurs 19.54 times per 100,000 people annually. Postoperative delirium (POD) is a sudden loss of awareness, attention, cognition, and perception after surgery. POD after trauma spine surgery ranges from 0.49 to 21%. NSE is an enzymatic protein found in neurones and neuroendocrine cells. After brain or nervous system trauma, NSE is released into the bloodstream. NSE is a putative POD biomarker. Due to their increased risk of POD after spinal surgery for trauma under general anaesthesia, NSE's effect on POD is uncertain.

Objectives: This study examines the relationship between preoperative and postoperative NSE levels and POD in post-traumatic spine surgery patients undergoing general anaesthesia.

Methods: This study is an analytical observational study that examines the levels of NSE before and after surgery in patients who have undergone post-traumatic spine surgery while under general anaesthesia. Blood samples were collected prior to surgery and 24 hours post-surgery to obtain data on NSE levels. The assessment of POD was conducted once the patient regained full consciousness following the procedure.

Results: The study included 25 male participants and 10 female participants, with 4 of the males experiencing POD. The correlation analysis revealed a statistically significant difference in NSE levels before and after surgery (p<0.001). However, there was no significant correlation between changes in NSE levels and POD (p=0.468).

Conclusions: The NSE levels saw a considerable increase after post-traumatic spinal surgery with general anaesthesia, however this increase was not significantly associated with the occurrence of POD.