Comparative Evaluation of Antidiabetic Properties in Ethanolic Extract fractions of Callistemon lanceolatus and Maytenusemarginata

Abstract

Present study investigates about the antidiabetic activity of Maytenusemarginatus and Callistemonlanceolatus ethanolic extract fractions (Ethyl acetate fraction and Methanol fraction) in streptozotocin (STZ)- NAD induced diabetic rat model. Maytenusemarginatus commonly known as Ding Hou belonging from Celesteraceae family and Callistemon lanceolatus commonly known as Bottle brush belonging from Myrtaceae family were selected and leaves extract was prepared using solvent ethanol (95%). Ethanolic crude extract was successively extracted with solvents of increasing polarity where EAFCL and MFME was selected based on antioxidant activity for further in vivo antidiabetic study. Seven groups were designed to proceed the study. The extract was administered orally for twenty-eight days, and various parameters including FBS levels, RBS levels, HbA1c, serum insulin, cholesterol level were evaluated. Hence, when compared to the diabetic control group, the results showed a substantial decrease in the fasting blood glucose levels in Groups III, IV, V, and VI. Sr. Insulin (Serum Insulin) levels were substantially raised in Groups III, IV, V and VI, indicating improved pancreatic beta-cell function. Treating diabetic rats with plant extracts led to a significant decrease in levels of HbA1C. This could be attributed to an improvement in glucose metabolism and glycaemic control. Overall, Maytenusemarginatus extract showed promising antidiabetic activity as compared to Callistemon lanceolatus, but both can be used in combination for antidiabetic activity which can act as natural alternative for diabetes management.