To Determine the Prognostic scoring systems (Sokal, Hasford and ELTS) in CML-CP patients and correlation between Haematological parameters

Abstract

Introduction: The primary goal of CML management is to stratify patient’s risk to identify the most optimal therapeutic regimen. The Sokal, Hasford and ELTS risk ratings were developed to predict patients on treatment. Aim: To perform a comparative study of CML prognostic indicators (Sokal, Haslford, and ELTS) at Swami Rama Himalayan University CML-CP patients with their demographical and haematological parameters. Method: This is a retrospective study performed on 71 Ph+ CML-CP patients who were never administered imatinib orally and study their demographical and haematological data. 30/71 were females and 41/71 were males with median age 38 years (range 18-75 years). 3(4.22%), 27(38.02%) and 41(57.75) patients were discriminated into low, intermediate and high risk in Sokal score respectively. 12(16.90%), 37(52.11%) and 22(30.99%) patients were discriminated into low, intermediate and high risk of Hasford score respectively and 5(7.04%), 28(39.44%), 38(53.52%) were patients divided into low, intermediate and high respectively of ELTS. Conclusion: The study found that Sokal and ELTS significantly predict treatment outcomes for CML-CP patients taking imatinib, and patients aged 20-39 are highly effective.