Acute Oral Toxicity Study Of Vatsanabh (Aconitum Ferox Wall)

Abstract

Vatsanabh(Aconitum ferox Wall) is one among the mahavishas the potent toxic drugs explained by Bruhattrayees. After processing, it is also a powerful plant that is currently recognised by humanity and used to treat a few illnesses. Inappropriate use or accidental ingestion can result in various signs and symptoms that might lead to potentially fatal conditions. The main objective of this study is to determine the toxicity dose(LD50) of Vatsanabh. Swiss albino mice were used for the present study. The LD50 value of Vatsanabh deteremined according to the OECD 425: Up and Down Procedure. Various dosage levels were tested, starting from a concentration of 175mg/kg. The study employed close monitoring of motor activity, convulsions, and other physiological parameters to evaluate the drug toxicity. The research ultimately aimed to establish the lethal dose (LD50) of Ashuddha Vatsanabh. Following the toxicity assessment, it was determined that the LD50 dose was approximately 550 mg/kg. The quantitative analytical examination of Vatsanabh is suggested by this study to strengthen the toxicological analysis.