The Impact of Topically Applied 0.5% Nifedipine Gel in Nonsurgical Treatment of Periodontitis

Abstract

Background: Periodontitis is a condition that affects the supporting tissues of the teeth and is increasing more common worldwide,

Aim: To evaluate the clinical, radiographic and biochemical efficacy of 0.5% Nifedipine gel as a local delivery following the non-surgical periodontal therapy in periodontitis patients (Stage II, Grade A),

Patients and methods: The present study was designed as a split-mouth randomized controlled clinical, radiographic, and Immunohistochemical study carried out on 20 patients of both sexes at Oral Medicine and Periodontology Department, Faculty of Dental Medicine, Al-Azhar University, Assiut Branch. They were diagnosed by recording the case history and performing extra oral and intraoral clinical examinations as well as radiographic evaluation,

Results: There was no significant difference between Group I and Group II regarding plaque index baseline, gingival index baseline, probing pocket depth baseline, BFGF baseline, and marginal bone level baseline p>0.05. However, significant differences were observed after one, three, and six months p<0.05, with no significant difference between Group I and Group II regarding BFGF after two weeks and one month,

Conclusion:  We concluded that the use of a 0.5% in situ gel of nifedipine, when applied topically, can effectively reduce probing pocket depth and increase attachment level in patients with stage II grade A periodontitis, and improve radiographic marginal bone level more effectively than non-surgical periodontal treatment alone.