Retardation of hepatic lipid accumulation and insulin resistance by ethanol extract of Garcinia cambogia in high fructose fed rats

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. Dr. R. Sripradha, Dr. M G Sridhar, Dr. Maithili Karpaga Selvi. N,

Abstract

The study investigated the effects of Garcinia cambogia extract (GE) on hepatic lipid accumulation and insulin resistance in high fructose fed rats. Forty male Wistar rats were divided into four groups (N=10). Two groups received standard rodent diet, two groups received 60% fructose diet and 400 mg/kg body weight of GE was given to each of the two diet groups for an experimental duration of ten weeks. GE administration decreased relative organ mass (liver, adipose tissue, epididymis), lipid ratios (TC/HDL-C, TAG/HDL-C, AIP, Non HDL-C/HDL-C), CRP, glucose, insulin, HOMA-IR and increased adiponectin levels in fructose fed rats. Treatment with GE reduced liver TAG content, hepatic expression of


SREBP-1c (86%), ACC (79%), FAS (81%), COX-2 (86%), oxidative stress and PKC-θ phosphorylation (67%) in skeletal muscle of fructose fed rats. GE supplementation decreased fructose induced hepatic fat accumulation and improved insulin sensitivity.  

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