Leucine Rich Peptides in Dentistry and Their Application in Orthodontics: A Scoping Review

Abstract

Objectives

The present scoping review aims to summarize existing literature on the use of Leucine Rich Amelogenin Peptides (LRAP) in dentistry and orthodontics, focusing on their potential applications, limitations, and future directions. LRAP is gaining interest for its ability to promote enamel formation, remineralization, and bone regeneration. This review highlights the therapeutic role of LRAP in dental treatments and addresses the gaps in current research.

Methods

This review followed PRISMA-ScR guidelines. A comprehensive literature search was performed in PubMed, Medline, Scopus, and Web of Science databases up to May 2024. A total of 80 articles were screened, and eight met the inclusion criteria. The included studies focused on the role of LRAP in enamel formation, remineralization, and bone health.

Results

Two articles explored LRAP's role in enamel formation, while five investigated its potential in remineralizing enamel. One study examined the effects of LRAP in preventing bone loss.

Conclusion:

LRAP significantly contributes to enamel formation, hydroxyapatite crystal formation in demineralized enamel lesions, and bone loss prevention. Further research is needed to optimize LRAP's clinical applications, especially in orthodontics, and to explore its full potential in dental tissue engineering.