An Evaluative Study Of Serum Adiponectin And Lipid Profile Level In Newly Diagnosed Hypertensive Patients In Garhwal Region Uttarakhand.

Abstract

Background: Hypertension is a major public health problem due to its high prevalence all around the globe. Hypertension is prevalent in 34.5% of urban north Indians. Elevated BP is positively correlated to the risk of stroke and coronary heart disease and other related complications.

Aim: To evaluate the level of Serum adiponectin and lipid profile in newly diagnosed hypertensive patients and to find out the association between them.

Method: The current study was conducted in the Garhwal Region of Uttarakhand. A total of 384 subjects, including 192 newly diagnosed hypertensive subjects as cases and 192 age and sex matched subjects as control group, were enrolled. Patients with chronic illness, pregnancy, substance abuse, Type-1and Type-2 diabetes, and any other illness were excluded from the study. Subjects with age range of 30 -70 years were selected. Lipid profile and adiponectin were estimated in both groups.

Result: In our study, we have observed a lower level of adiponectin in cases as compared to the control group, which was found to be statistically significant(p<0.01). High levels of Serum cholesterol, serum triglycerides, LDL, and VLDL and serum HDL were found low in newly diagnosed hypertensive cases as compared to Healthy Controls.

Conclusion:

Low levels of plasma adiponectin may be employed as an independent predictive risk factor for developing hypertension along with a deranged lipid profile