Elevated E-Selectin Levels and Their Correlation with Blast Cells in Acute Myeloid Leukemia Patients

Abstract

A B S T R A C T:

Background: Acute myeloid leukemia (AML) is a highly aggressive blood cancer characterized by the accumulation of immature myeloid cells in the bone marrow, disrupting normal blood cell production. Unfortunately, AML carries a grim prognosis, with a substantial rate of disease, relapse, and a median overall survival of only 15 months. A vascular adhesion molecule called E-selectin is only found on activated endothelial cells. It controls the activity of hematopoietic stem cells (HSCs) in the bone marrow vascular niche and is very important for this.Evaluation The level of E-selection in AML patients as well as the correlation between E-selectin and blast cells. This study case control included a total of 50 patients with AML collected from "National center of hematology /Mustansiriyah university" from January 2022 to June 2023. twenty-five out of 50 AML patients was new diagnosis and other 25 AML patients after therapy, The age and sex matched with 50 apparently healthy individuals as control group. Blood was taken from them for an evaluation of their E-selectin level using Sandwich ELISA method. There are significant differences in the level of E-Selectin concentration in AML patients' plasma compared with the concentration of healthy group plasma. While there is no significant difference between patients before and after chemotherapy, there is a significant correlation between E-selectin level and blast cells. The level of E-selectin is elevated in AML patients, and there is an appositive correlation between E-selectin and Blast cells, which may contribute to the progression of the disease.