“Clinical Evaluation of Guduchyadi Kwath in the Management of Ekakustha With Special Reference to Psoriasis: A Randomized Controlled Trial”

Abstract

Introduction: Psoriasis is a widespread, chronically recurrent papulosquamous illness characterized by varying sized silvery-white, scaly patches most typically observed on the elbow, knees, and scalp but ultimately covering the entire body. The most prevalent consequences in psoriasis patients include cardiovascular disease (CVD), Crohn's disease, chronic obstructive pulmonary disease (COPD), cancer, depression, and metabolic syndrome. Ayurvedic drugs need to be studied for their clinical efficacy and safety in skin diseases with high burden in society. Aim and Objectives: To compare the efficacy of Guduchyadi Kwath in the management of Ekakustha w.s.r. to Psoriasis with a controlled group of modern medicine (Tablet Methotrexate, Tablet Folic Acid & Psorinol ointment). Material and Methods: 32 patients of psoriasis were randomly divided into two groups. In Group A, 16 patients were administered Guduchyadi Kwath whereas in group B, 16 patients were given Methotrexate tablet, Folic acid tablet and Psorinol ointment for 28 days. Results: 30 patients completed the study and both interventions were found effective and led to significant reductions in Psoriasis Area and Severity Index Score (PASI Score), Hamilton Depression Rating Scale (HDRS),

Asvedana (Loss of perspiration), Mahavastu (Extent of lesion), Matsyashakalopama (Scaling), Krishna Aruna Varna (Discoloration), Kandu (Itching) and Rukshata (Dryness) after 28 days of therapy. Conclusion: Standard control drug (Tablet Methotrexate) exhibited better results compared to Guduchyadi Kwath (Trial drug) in improving the primary as well as secondary outcome measures.