Restoration Of Lung Function By Aerobic Vs Anaerobic Exercise: Insights From MDA, TNF-Α, And SOD Expression

Abstract

Introduction: Aerobic and anaerobic exercises play distinct roles in lung function improvement, each impacting the respiratory system through different mechanisms. Aerobic exercise enhances cardiovascular endurance and respiratory efficiency, while anaerobic exercise focuses on strengthening respiratory muscles and improving short-term oxygen utilization.

Objectives: The aim of this study was to compare the effects and duration required for aerobic and anaerobic exercise to restore lung function, focusing on the expression of malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), and superoxide dismutase (SOD). These biomarkers were selected due to their roles in oxidative stress, inflammation, and antioxidant defense mechanisms, respectively.

Methods: An experiment was conducted involving four groups: negative control, positive control, aerobic exercise and an anaerobic exercise group, each consisting of five Wistar rats. The experimental protocol included a smoking exposure period of 20 days, followed by aerobic and anaerobic training for five days a week for eight weeks. MDA, TNF-α and SOD expressions were measured by immunohistochemistry techniques

Results: The results demonstrated that both aerobic and anaerobic exercises significantly improved lung function compared to the control groups. Improvements in lung function, indicated by reductions in MDA and TNF-α expressions and increases in SOD expression, were observed as early as day 20 post-treatment in both exercise groups. The study found no significant differences between aerobic and anaerobic exercise in terms of their impact on MDA, TNF-α, and SOD expressions..

Conclusions: In conclusion, this study provides valuable insights into the mechanisms by which aerobic and anaerobic exercises promote lung health, emphasizing the importance of regular physical activity in managing respiratory conditions