Insights Of Herbal Tablets Derived From Terminalia Chebula Extract: Characterization Of In Vitro Activity In Male Wistar Rats
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Abstract
Diabetes mellitus is a category of metabolic disorders that cause hyperglycaemia due to inadequate insulin secretion, insulin resistance, or both, and are associated with irregular metabolism of carbohydrates, fats, and proteins. The aim of present research was to evaluate anti-diabetic potential of herbal tablets derived from Terminalia chebula extract using carbapol and gelatin as excipient. Diabetes was induced by injecting 150 mg/kg of alloxan monohydrate diluted in saline intraperitoneally. Blood glucose levels in two animal groups were studied in response to two different herbal tablets batches that contained Terminalia chebula extract. Wistar rats were given an oral dose of 200 mg/kg of carbopol-containing Terminalia chebula tablets, which significantly decreased the biochemical parameters in alloxan-induced diabetic rats. Anti-diabetic efficiency of Terminalia chebula extract could be attributed to increase in insulin production from pancreatic beta cells, or else it could be because of insulin stimulatory effects. Treatment of Terminalia chebula in rats suffering with diabetic resulted in weight gain, indicating that Terminalia chebula extract has a positive impact.