Double-edged sword: Conservative functions of BioGlue in healing of tooth extraction wound

Abstract

BACKGROUND: Healing refers to the replacement of damaged tissue by new           

                         bodily tissue to restore its normal form and function. Healing of extraction          

                         wounds constitutes a number of complex events for the restoration of tissue          

                         integrity. The use of N-Butyl Cyanoacrylate, a haemostatic agent and BioGlue  in the healing of extraction wounds, prove to make the complex process of healing much more accelerated and efficient to re-establish functional and structural forms.

                        AIMS: 1.) To assess the role of BioGlue (N-Butyl Cyanoacrylate) in the healing extraction wounds.

                                  2.) To compare wound healing in extraction wounds with and without BioGlue (N-Butyl Cyanoacrylate).

METHODS/MATERIALS: Extraction wounds were taken as as two groups, one w               without the BioGlue and the other, with BioGlue. The cyanoacrylate glue was                 administered to the extraction wound and was assessed for rate of wound healing.                                                 

RESULTS: we found enhanced reduction in the width of the extraction wound in the wound with BioGlue while comparing it to those without. We found an increased mean total inflammatory score in the 1st week, increased remodelling score in the 4th week as well as the total IPR score in the wounds with the BioGlue when compared to those without. The parameters of inflammatory scale in the first week that showed significant difference were tissue colour, edema, pain in the wounds with the BioGlue. The remodelling scale parameters that showed a significant difference is tissue colour in those wounds with the BioGlue. The Landry,Turnbull and Howley index at both the 1st and 4th week showed an  increased healing score in the wounds with the BioGlue than when compared to those without the glue.

CONCLUSION: To our knowledge, the rates of healing of extraction wounds are significantly influenced by the administration of N-Butyl Cyanoacrylate. The supportive data of assessment of the same also has inferred that there is significant clinical reduction in post operative symptoms, reduced chance of clot dislodgement as well as better overall environment for healing