Studies on The Regulation of Aromatase For Brain Derived Estrogen: A Systematic Review

Abstract

Despite being traditionally recognised as an ovarian endocrine signal, 17β-estradiol (E2) is also a neurosteroid that is generated in the brains of several animals by neurones and astrocytes. The location, regulation, sex variations, and physiological/pathological significance of brain-derived E2 (BDE2) are all well covered in this review. Studies employing particular inhibitors of the E2 production enzyme, aromatase, and the subsequent creation of conditional forebrain neuron-specific and astrocyte-specific aromatase knockout animal models have provided a large portion of our knowledge about the physiological roles of BDE2. According to the data from these investigations, neuron-derived E2 (NDE2) plays a crucial part in the control of memory, synaptic plasticity, sexual differentiation, reproduction, injury-induced reactive gliosis, neuroprotection, and sociosexual behavior.