Bio-Analytical Method Development and Validation for Determination of Anti-Retroviral Drug (Covid-19) Remdesivir in Rat Plasma by using Novel RP-HPLC

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P. Sathya Sowmya, Dr. N. Harikrishnan

Abstract

A dependable and validated bio-analytical method that makes use of Reverse Phase High Performance Liquid Chromatography (RP-HPLC) was used in this investigation in order to accurately detect the quantities of Remdesivir that were present in the plasma of rats. The method was able to exhibit excellent accuracy, sensitivity, selectivity, and precision in accordance with the parameters established by the United States Food and Drug Administration (FDA). The efficacy and reliability of the technique were both improved as a result of the remarkable recoveries that were obtained from the sample extraction process employing basic protein precipitation. Statistical techniques were used to conduct an analysis of the data, which confirmed that the approach that was provided is suitable for conducting bioequivalence testing and routine commercial analysis of Remdesivir samples in drug samples and drug goods. Remdesivir formulations may be efficiently tested pharmacokinetically and quality control assessed using this proven technique. This is made possible by the integrity and effectiveness of this essential antiviral medicine.

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