Optimizing Doxycycline delivery through Chitosan Polyelectrolyte Complexfilms: Development and Characterization
Main Article Content
Abstract
In this study, doxycyclineloaded chitosan polyelectrolyte complex films were developed using xanthan gum and pectin to achieve controlled drug release for biomedical applications. The polyelectrolyte complexes were characterized through various tests, including physicochemical analysis, moisture content, swelling index, water vapor transmission, drug content, and Fourier Transform Infrared Spectroscopy (FTIR). The in vitro release of doxycycline was examined in pH 7.4 buffer at 37°C. The release data were interpreted using various kinetic models, with the Korsmeyer-Peppas model showing the best fit. The doxycyclineloaded PEC films demonstrated good antibacterial activity againstStaphylococcus aureus. The prepared films were appropriate for slow and sustained release of doxycycline over a 24-hour period, deemed to be ideal for use as antimicrobial wound dressings.