Canagliflozin: A Literature Review On Analytical And Bioanalytical Method
Main Article Content
Abstract
Sodium-Glucose cotransporter-2 (SGLT2) inhibitors have emerged as a promising therapeutic option for the treatment of type-II diabetes, offering a new approach to managing the disease. Various analytical techniques have been employed to analyze Canagliflozin in biological samples. Spectroscopic methods, such as chromogenic and derivative techniques, have been utilized for qualitative and quantitative analysis of Canagliflozin. High-performance liquid chromatography (HPLC) and Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) are among the most commonly used methods for the analysis of Canagliflozin in biological matrices. This review aims to provide a comprehensive overview of the analytical methods used for the analysis of Canagliflozin. It highlights the different spectroscopic and chromatographic techniques employed, as well as the sample processing options, chromatographic/detection settings, and validation parameters used in these methods. By compiling this information in a systematic manner, this review serves as a valuable resource for analysts looking to develop and validate analytical methods for Canagliflozin and similar drugs.