Design and Development of Biodegradable Hydrogel-Based Matrix Systems for Sustained and Targeted Delivery of Ibuprofen: Enhancing Bioavailability and Therapeutic Efficacy in Chronic Inflammatory Disorders

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Jisha Annie Geevarghese, Arpan Dutta, Sanghadeep Gajbhiye, Mohammed Khalid, Anil Kumar, Navesh Veer, Sushisha Tripathy, Ekta Pandey, Manu Jose

Abstract

Background

Chronic inflammatory disorders are prevalent conditions requiring long-term management, often with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Conventional ibuprofen delivery faces challenges such as short half-life, poor bioavailability, and systemic side effects. Biodegradable hydrogels offer a promising platform for sustained and targeted drug delivery to overcome these limitations.


Objective

This study aimed to design and develop hydrogel-based matrix systems for the sustained and targeted delivery of ibuprofen, enhancing its bioavailability and therapeutic efficacy while minimizing dosing frequency and side effects.


Methods

Biodegradable hydrogels were prepared using alginate and gelatin, cross-linked with calcium chloride, and optimized for ibuprofen encapsulation. Physicochemical properties, including swelling behavior, degradation, and surface morphology, were characterized. Drug loading efficiency and in vitro release kinetics were evaluated. Pharmacokinetics and anti-inflammatory efficacy were assessed using animal models, and statistical analyses were conducted to determine significance.


Results

The hydrogels demonstrated high swelling capacity (500% ± 15%), complete biodegradability within 21 days, and a porous structure suitable for drug encapsulation. Encapsulation efficiency ranged from 75% to 92%, and sustained drug release was achieved over 48 hours, adhering to the Higuchi model. Pharmacokinetic studies showed a 2.5-fold increase in bioavailability with delayed T_max and reduced C_max compared to free ibuprofen. Anti-inflammatory efficacy was significantly improved, with a 65% reduction in paw swelling observed in animal models.


Conclusion

Biodegradable hydrogel-based matrix systems provide a viable solution for sustained ibuprofen delivery, offering enhanced bioavailability and prolonged therapeutic efficacy. These systems hold significant potential for managing chronic inflammatory disorders, with future directions focusing on clinical translation, scalability, and customization for other therapeutic agents.

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