Fabrication, Characterization and in Vitro Evaluation of Polymeric Nanoparticles Loaded with Anticancer Drug

Abstract

  Anticancer drugs like Paclitaxel are effective in treating a variety of cancer forms. However, due to its poor solubility, paclitaxel is manufactured commercially using ethanol and Cremophor EL, or Taxol. Sadly, there are major negative effects linked to this Cremophor EL. Therefore, novel delivery methods are needed to increase anticancer efficacy and decrease adverse effects in order to remove the Cremophor EL-based vehicle. Preparing polymeric nanoparticles loaded with Paclitaxel, an anticancer medication, and assessing the experimental nanoparticle preparation were the primary goals of this work. The objective of the study was to create polymeric nanoparticles utilizing TPGS, PVA, and PLGA. The process of double-emulsion solvent evaporation was utilized to generate polymeric nanoparticles loaded with paclitaxel. It was discovered that the optimized formulation's mean particle size, polydispersity index, zeta potential, drug loading, drug entrapment efficiency, and drug release were all satisfactory. According to the kinetic analysis of the in vitro release, the medication releases according to the "Fickian diffusion" theory proposed by Korsmeyer Peppas. Therefore, it can be said that the formulation created in this study offers promise as an anticancer drug delivery method for long-term cancer therapeutic treatment.