Formulation Of Atenolol Novel Cardiovascular Lipid Nanocarrier Transferosome.

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N. Kanagathara, L. Jeyanthi Rebecca, S. Jaikumar

Abstract

The beta-blocker atenolol has a wide variety of uses in the management of cardiovascular disease. An enhanced atenolol delivery system was developed and optimized in this study using lipid nanocarrier transferosomes. A nanostructured lipid carrier formulation was prepared by a number of techniques. The optimized formulation was then assessed for particle size, zeta potential, scanning electron microscopy, and drug encapsulation efficiency. Atenolol-loaded cardiovascular lipid nanocarrier transferosomes demonstrate a promising potential for enhanced drug delivery. Physicochemical properties and sustained release characteristics of the optimized formulation suggest improved efficacy and compliance for patients. The developed transferosomal formulation must undergo further preclinical and clinical studies to determine its therapeutic potential and pharmacokinetic profile.

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