Outcome of Preoperative Steroid Injection on Wound Drainage after Modified Radical Mastectomy

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Bezan Baloch, Fida Ahmed, Abdullah Khan, Nazeer Ahmed Sasoli, Samina karim, Saleem Javed

Abstract

Background: The prevalence of Breast cancer is increasing. Modified radical mastectomy is one of the available treatment options, is performed with the goal of curing the condition. More than 35% of patients had morbidity following surgery.


Objective: The aim of this study was to determine the outcome of Preoperative Steroid Injection on Wound Drainage after Modified Radical


Methodology: This current study was carried out at the department of surgery Bolan Medical Complex Hospital Quetta Balochistan for a period of six months from January, 2023 -June, 2024 after taking permission from the ethical board of the hospital. A total of 62 females with breast cancer and  were planned for modified  radical  mastectomy were included. The patients were assigned computer-generated numbers to form two equal groups, A and B. An hour before to surgery, group A received a 120 mg a day (3 ml) injection of depomedrol, while group B received 3 ml of regular saline. The same consultant surgeon conducted MRM on both groups using the same dissection technique, which is steel scalpel dissection. Two suction drains, one at the breast site and one at the axillary area, were positioned at the end of the treatment. Every patient received the same routine preoperative and postoperative treatment. After the drain was taken out, the volume of the drain was measured using operational criteria. Data was analyzed through SPSS 25.  


Results: A total of 62 females participated in this study. 48.3% were diagnosed with stage II breast cancer, and 51.7% had stage I. When the mean drainage volume (in milliliters) of the two groups was compared, it was found that in individuals having a modified radical mastectomy, a single preoperative steroid dose reduced mean drainage volume more than control. This variance was not noteworthy ( t-test value of 4.078 and value of P 0.048). There was no impact of these effect modifiers on the mean drainage volume for age, Body mass index, symptoms duration , and illness stage using  t-test.


Conclusion: Our findings showed that that the preventive steroid injections prescription in women following modified radical mastectomy were more effective in lowering mean drainage volume for female participants with stage I and II breast cancer when compared to normal saline

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