Evaluation Of Analgesic Activity Of Siddha Formulation Karunkurinji Kudineer In Wistar Albino Rats

Abstract

This study aimed to evaluate the analgesic efficacy of Karunkurinji Kudineer. A total of four groups of six albino rats each were established: Group I received distilled water, Group II received 10 mg/kg of aceclofenac sodium, Group III received 10 mg/kg of Karunkurinji Kudineer, and Group IV received 20 mg/kg of Karunkurinji Kudineer. The acetic acid-induced writhing method was employed to assess the analgesic effect. The group I exhibited the highest number of writhes (37.2±2.3), while the aceclofenac sodium group had the lowest (7.9±0.6). Group IV demonstrated a significant reduction in writhes (11.6 ±0.8) compared to Group III (12.0±1.2). Statistical analysis yielded significant results (P<0.05). These findings suggest that the Siddha formulation Karunkurinji Kudineer possesses analgesic efficacy and may serve as an alternative treatment for painful conditions.