An Immunohistochemical Diagnostic Approach of Clear Cell Calcifying Epithelial Odontogenic Tumor of Anterior Mandible

Abstract

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm reported to be less than 1% of all odontogenic tumors. Dr. J J Pindborg in the year 1958 first described this lesion after which Shafer et al termed it as Pindborg tumor. This tumor is a locally aggressive benign neoplasm of odontogenic epithelial origin. The clear cell variant of CEOT (CCEOT) is more aggressive with highest recurrence rate of about 22%. Howell and Abrams reported the first case of CCEOT in the year 1967. Hence it is crucial to consider clear cell variant in histopathological diagnosis. Such a rare case of CCEOT is reported in our institution and its clinical, radiographical and histopathological features are discussed in this article. This rare case report gives an overview of a clear cell variant of CEOT in the anterior mandible of a 62-year-old female patient.