Synthesis and Characterization of New Azolidinone Derived from Creatinine and Study their Biological Activity

Abstract

This work consists of preparation new compounds using creatinine as a starting material carried out in four stages, where in the first stage, creatinine reacts with chloroacetyl chloride, leading to formation compound (1) which enters into the reaction of the second stage with hydrazine hydrate (99 percent), giving compound (2). In the third stage, aromatic aldehyde is used to prepare Schiff base compound(3).The resulting Schiff bases are used in ring-closing reactions with glycine, glycolic acid and thioglycolic acid to yield (4, 5, 6) respectively as final product. The organized compounds were uniqued by using IR spectroscopic method and"¹HNMR. The biological activity diagnosed for the prepared compounds and showed promising results.

The work aims to study the properties of creatinine derivatives and determine their effectiveness and biological attributes