COMPARISON OF CONVENTIONAL AND MODIFIED GLEASON GRADING SYSTEMS

Abstract

OBJECTIVE: To determine the frequency of patients who show change in conventional Gleason score of prostate adenocarcinoma by the application of modified Gleason grading system

STUDY DESIGN Cross sectional survey.

Place and duration of study: Department of pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore.  Six months after approval of synopsis time duration

material and methods:100 cases of prostatic adenocarcinoma were given a Gleason score by applying conventional Gleason grading system and Modified (ISUP 2005) Gleason grading. Information was collected on a Performa. Patient’s name, age, histology numbers, the change in Gleason score, presence of tertiary tumor grade pattern and any other morphological variation were recorded.

Results: 41 cases showed change in gleason score after the application of modified gleason grading system. the gleason score was upgraded in these  cases. none of the case showed  downgraded .gleason score .

conclusion: The application of modified gleason grading system changes gleason score in significant number of  cases  with upward migration.