Potential Antimicrobial and Anti-Ulcer Properties of a Solvent Extracted Active Constituent from Amaranthaceae Family

Abstract

Background and Aim: Medicinal herbs can be used as antacids in a number of Ayurvedic treatments and are a rich source of antibacterial properties. Many artificial antacids are frequently used to treat hyperacidity. Nevertheless, drugs made from plants may work well for creating new antacids. Therefore, the purpose of the current study was to evaluate the acid-neutralizing and antibacterial properties of an extract of native plants belonging to the Amaranthaceae family. Methodology: Fordtran's model titration method was used to ascertain the neutralization capability in vitro. The broth dilution method was used to determine the minimum inhibitory concentration (MIC), and the disc diffusion method was used to evaluate antibacterial activity. Result: The result of this study showed, 100 mg of Methanolic extract of Achyranthes aspera (MEAA) and Water extract of Achyranthes aspera (WEAA) had a stronger acid neutralizing effect. At a concentration of 250 g/disc, the highest activity of plant extract in MEAA was observed at 26.00 mm diameter ZOI against P. vulgaris, followed by 25.00 mm diameter ZOI against E. coli. Next was Methanolic extract of Amaranthus spinosus (MEAS), which has a 21.00 mm ZOI against E. coli. Conclusion: Out of all the extracts examined, MEAS and MEAA extracts exhibited the highest capacity to neutralize acids. In vitro, MEAS extract showed the highest antibacterial activity against both gram-positive and gram-negative bacteria.